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Microwave Assisted Rapid Synthesis of (Arylselanyl)phenyl-1H-1,2,3-triazoles by Copper Catalyzed 1,3-Dipolar Cycloaddition

[ Vol. 3 , Issue. 1 ]


Mauricio C.D.F. Xavier, Daiane M. Xavier, Natália Seus, Eder J. Lenardão, Gelson Perin and Diego Alves   Pages 14 - 23 ( 10 )


We describe here a simple and rapid protocol for the synthesis of (arylselanyl)phenyl-1H- 1,2,3-triazoles by copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions using Microwave Irradiation. The products were obtained under mild conditions in excellent yields in a short reaction time by reacting azidophenyl arylselenides with a range of terminal alkynes using catalytic amount of Cu(OAc)2.H2O/sodium ascorbate. This Click Chemistry protocol is an efficient method to synthesize new selenium compounds with potential application in biological studies and materials sciences.


Alkynes, azides, catalysis, 1, 3-dipolar, click chemistry, copper, cycloaddition, green chemistry, heterocycles, microwave, 1, 2, 3-triazoles, nitrogen compounds, selanyltriazoles, selenium compounds.


LASOL - CCQFA - Universidade Federal de Pelotas - UFPel - P.O. Box 354 - 96010-900, Pelotas, RS, Brazil.

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