Rajesh H. Vekariya, Shyamali N. Panchal, Kinjal D. Patel and Hitesh D. Patel Pages 61 - 68 ( 8 )
An exceptionally efficient, environmentally safe and economic method has been developed for regioselective α-bromination of various aralkyl ketones in excellent yield with N-bromosuccinimide (NBS) under microwave irradiation (CEM discover) without use of either a solvent or a catalyst. After completion of the reaction, the NBS can be regenerated by using an environment friendly brominating agent NaBr/NaBrO3 in acetic acid. The present procedure offers various advantages such as a very short reaction time, simple work-up procedure, excellent yield of products and recovery of the reagents by green protocol.
α-bromination, catalyst free, efficient protocol green bromination, microwave irradiation, N-bromosuccinimide, regeneration, regioselectivity, solvent free.
Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, India.