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Microwave and Conventional Method Assisted Synthesis of 2-(substituted) -3-(4-methoxybenzyl) Thiazolidin-4-ones Using ZrOCl2·8H2O as a Catalyst

[ Vol. 4 , Issue. 2 ]

Author(s):

Aniket P. Sarkate, Dattatraya N. Pansare, Ishwari A. Kale and Devanand B. Shinde   Pages 139 - 145 ( 7 )

Abstract:


Background: Although several methods are reported for the synthesis of thiazolidin-4-ones analogues, the microwave assisted method reported in this work is simple and proceeds with high yields in short time.

Methods: In the synthetic method, the targeted thiazolidin-4-ones were synthesized with the help of the microwave by reacting aldehydes, benzyl amine and thioglycolic acid in the presence of zirconium oxychloride and ethanol.

Results: All the thiazolidin-4-ones were obtained in good yield (95%-98%) with the help of a microwave technique (6-8 min), in less time as compared to the conventional method (2-4 h).

Conclusion: Microwave assisted synthesis will be a useful alternative method for the synthesis of diverse range of thiazolidin-4-ones.

Keywords:

Aromatic aldehydes, microwave irradiation, ZrOCl2·8H2O.

Affiliation:

Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, MS, Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, MS, Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431 004, MS, Shivaji University, Vidyanagar, Kolhapur 416 004, MS

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