Article Details


Microwave Assisted Copper-catalyzed Synthesis of Substituted Benzamides Through Decarboxylative C-N Cross Coupling

[ Vol. 4 , Issue. 2 ]

Author(s):

Aniket P. Sarkate, Dattatraya N. Pansare, Kshipra S. Karnik, Ishwari A. Kale, Sushilkumar S. Bahekar and Devanand B. Shinde   Pages 163 - 167 ( 5 )

Abstract:


Background: An efficient, microwave assisted, copper catalyzed synthetic protocol for substituted benzamides has been developed by using salts of carboxylic acids.

Methods: In the synthetic method, the targeted substituted benzamides were synthesized with the help of microwave by reacting salts of carboxylic acid and benzamides in the presence of copper and dimethyl formamide.

Results: All substituted benzamides were obtained in good yield (93-99%) with the help of a microwave technique (12-15 min) in the less time as compared to the conventional method.

Conclusion: Microwave assisted technique will be a useful alternative protocol for the preparation of diverse range of substituted benzamides.

Keywords:

Benzamides, copper, coupling, microwave, synthesis.

Affiliation:

Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004 (MS), Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004 (MS), Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004 (MS), Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004 (MS), Bond Life Sciences Pvt. Ltd., Aurangabad, 431004 (MS), Shivaji University, Vidyanagar, Kolhapur- 416 004(MS)

Graphical Abstract:



Read Full-Text article