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Copper Catalyzed Ligand Free Microwave Mediated Synthesis of α-ketoamides from Aromatic Ketones

[ Vol. 5 , Issue. 1 ]

Author(s):

Kshipra S. Karnik, Aniket P. Sarkate, Shritesh D. Jagtap and Pravin S. Wakte*   Pages 39 - 45 ( 7 )

Abstract:


Background: An efficient, microwave assisted, copper catalyzed synthetic protocol for α- ketoamides has been developed by using secondary amines.

Methods: In the synthetic method, the targeted α-ketoamides were synthesized with the help of microwave by reacting secondary amines and aryl methyl ketones in the presence of copper chloride and hydrogen peroxide.

Results: α-ketoamides were prepared in good yields (within 10mins) with the help of a microwave irradiation. The reported protocol is ligand free and the yields of the derivatives were modest to excellent.

Conclusion: Microwave assisted technique will be a useful alternative method for the preparation of α-ketoamides.

Keywords:

Aryl methyl ketones, copper chloride, microwave, secondary amines, α-ketoamides, synthetic protocol.

Affiliation:

Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, (MS), Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, (MS), Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, (MS), Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, (MS)

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