Bahittin Kahveci* and Emre Menteşe Pages 1 - 17 ( 17 )
Background: Microwave heating has been shown to be an invaluable technology for medicinal chemistry and drug discovery applications. Recently, it has been used for heterocyclic synthesis increasingly. This review article shows a work on the synthesis of coumarin derivatives by microwave- assisted heating. Methods: Microwave-assisted heating has been used for the synthesis of coumarin derivatives. There are some useful methods to obtain coumarin derivatives. The Knoevenagel condensation is the most prominent one with microwave heating. The other one is the microwave-assisted Vilsmeier-Haack reaction. Another one is microwave assisted convenient one-pot synthesis of coumarin derivatives via Pechmann condensation catalyzed by FeF3 under solvent-free conditions. In addition to these, Perkin condensation can also be used for the synthesis of coumarin derivatives under microwave heating conditions. Results: Coumarin derivatives have a pharmacological importance in drug discovery and dyes. Microwave irradiation is an effective method for the synthesis of coumarin derivatives and when compared to the conventional heating, it has many advantages. Conclusion: This review aimed to demonstrate the applications of microwave heating for the synthesis of coumarin derivatives from 2007 to 2018. It may be helpful to synthesize new coumarin derivatives as an alternative method that enables you to gain time and a new perspective.
Coumarins, microwave heating, conventional heating, multicomponent reaction, catalyst-free, cyclizations.
Department of Nutrition and Dietetics, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, Department of Chemistry, Faculty of Arts and Sciences, Recep Tayyip Erdoğan University, Rize