Syed Tajudeen Syed Ameen*, Anbalagan Vilvanathan, Syed Zameer Ahmed Khader and Gayathri Mahalingam Pages 222 - 229 ( 8 )
Background: A series of β-diketone hydrazones have been synthesized via condensation of isoniazid with series of β-diketone. The structures of the Schiff bases are established by elemental and spectroscopic techniques. The prepared compounds were screened for antibacterial and antioxidant potential by DPPH free-radical scavenging activity and Ferric reducing antioxidant power (FRAP) assays.Methods: β-diketone hydrazine derivatives were synthesized by simple condensation between various β-diketones and isoniazid. The titled compounds were synthesized following both conventional and microwave irradiation methods. The in vitro antibacterial activity of synthesized derivatives was evaluated against gram-positive (B. subtilis, S. aureus and S. pyogenes) and gram-negative (E. coli, and K. pneumonia) bacterial strains and expressed in terms of zone of inhibition and also screened for antioxidant activity. Results: The yield of products was appreciably increased in shorter reaction times with the aid of microwave-assisted synthesis. Therefore, it follows the green chemistry approach by making the above reactions eco-friendly. The synthesized compounds were characterized using FT-IR, 1H NMR, 13C NMR, and elemental analysis techniques. The spectroscopic techniques showed the formation of β-diketone hydrazone compounds. Theoretical data show good agreement with the experimental results. Some of the compounds displayed significant antibacterial and antioxidant potentials when compared to the standard drug. Conclusion: In the present research work, we report the synthesis of some novel β-diketone hydrazone derivatives. A high yield of compounds was noted under microwave-assisted reaction in shorter reaction times. The results revealed that the synthesized Schiff bases showed good radical scavenging activity.
β-Diketone, isoniazid, hydrazones, green synthesis, microwave, antibacterial, antioxidant study.
Department of Chemistry, C. Abdul Hakeem College, Melvisharam, Ranipet District, Tamil Nadu, Department of Chemistry, C. Abdul Hakeem College, Melvisharam, Ranipet District, Tamil Nadu, India, Department of Biotechnology, K.S.Rangasamy College of Technology, Tiruchengode, Tamil Nadu, Department of Biotechnology, School of Bio-Sciences and Technology, VIT University, Vellore, Tamil Nadu